Coumarin-based Hg2+ fluorescent probe: Fluorescence turn-on detection for Hg2+ bioimaging in living cells and zebrafish

doi:10.1016/j.saa.2019.04.048

Title:	Coumarin-based Hg2+ fluorescent probe: Fluorescence turn-on detection for Hg2+ bioimaging in living cells and zebrafish
Authors:	Chen, Chong-Guang Vijay, Natarajan Thirumalaivasan, Natesan Velmathi, Sivan Wu, Shu-Pao 應用化學系 Department of Applied Chemistry
Keywords:	Hg(II);Sensor;Coumarin;Bioimaging;Zebrafish
Issue Date:	5-Aug-2019
Abstract:	The need in developing fluorescent probes for trace metal ion detection in biological samples has been an important issue. Herein, a reaction-based fluorescent probe PIC containing a perimidine moiety was designed and synthesized for Hg2+ detection. The probe can selectively distinguish Hg2+ with 42-fold fluorescent enhancement from the other metal ions at physiological pH. This probe can detect Hg2+ with the detection limit of 1.08 mu M. The sensor PIC can be applied to real-time detection of Hg2+ in cells with blue emission. (C) 2019 Elsevier B.V. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.saa.2019.04.048 http://hdl.handle.net/11536/152174
ISSN:	1386-1425
DOI:	10.1016/j.saa.2019.04.048
Journal:	SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume:	219
Begin Page:	135
End Page:	140
Appears in Collections:	Articles